What is IMAP?
IMAP is a collective study trying to investigate the correlation between functional Magnetic Resonance Imaging (MR)I techniques and outcome measures and potential definition of tumour sub-volumes of different underlying physiology. For cervical cancer already numerous studies have reported the potential of techniqes such as Dynamic Contrast Enhanced (DCE) -MRI and Diffusion Weighted (DWI)-MRI. The aim of this study is to select patients that will benefit from current standard of treatment and those that will benifit from further treatment and closer monitoring.
Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) is a powerfull tool to evaluate tissue perfusion, permeability and vascularture. High temporal resolution scans are performed while the Gd-based contrast agent is introduced into the patietns blood stream and its subsequent dispersion os recorded. Numerous methods of analysing the temporal tissue enhancement profile have been proposed ranging from phenomelogical, semiquantitative and quantitative tracer kineticmodel (TKMs) .